Martin Luther University Halle-Wittenberg

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Publications

Original Articles

2023

Krumbein M, Oberman F, Cinnamon Y, Golomb M, May D, Vainer G, Belzer V, Meir K, Fridman I, Haybaeck J, Poelzl G, Kehat I, Beeri R, Kessler SM, Yisraeli JK. 2023. RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy. Commun Biol 2023 Dec 5;6(1):1229. doi: 10.1038/s42003-023-05547-x

Maji RK, Czepukojc B, Scherer M, Tierling S, Cadenas C, Gianmoena K, Gasparoni N, Nordström K, Gasparoni G, Laggai S, Yang X, Sinha A, Ebert P, Falk-Paulsen M, Kinkley S, Hoppstädter J, Chung H-R, Rosenstiel P, Hengstler JG, Walter J, Schulz MH*, Kessler SM*, Kiemer AK*. 2023. Alterations in the hepatocyte epigenetic landscape in steatosis. Epigenetics Chromatin 2023, 16:30

Kendzia S, Franke S, Kröhler T et al. A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer. 2023. Mol Cancer 22:89. https://doi.org/10.1186/s12943-023-01787-x   

2022

Brindisi M, Kessler SM, Kumar V, Zwergel C. 2022. Editorial: Multi-target directed ligands for the treatment of cancer. Front Oncol 2022, 12:980141

Köhler N, Höring M, Czepukojzc B, Rose TD,  Buechler C, Kröhler T, Haybaeck J, Liebisch G, Pauling JK, Kessler SM, Kiemer AK. 2022. Kupffer cells are protective in alcoholic steatosis. Biochim Biophys Acta Mol Basis Dis 1868:166398.

Dahlem C, Abuhaliema A, Kessler SM, Kröhler T, Zoller BGE, Chanda S, Wu Y, Both S, Müller F, Lepikhov K, Kirsch SH, Laggai S, Müller R, Empting M, Kiemer AK. 2022. The first small molecule inhibitors targeting the RNA binding protein IGF2BP2/IMP2 for cancer therapy. ACS Chem Biol 17:361-375.

2020

Dahlem C, Siow W-X, Lopatniuk M, Tse WKF, Kessler SM, Kirsch SH, Hoppstädter J, Vollmar AM, Müller R, Luzhetskyy A, Bartel K, Kiemer AK. 2020. Thioholgamide A, a new anti-proliferative anti-tumor agent, modulates macrophage polarization and metabolism. Cancers accepted

2019

Ramisch A, Heinrich V, Glaser LV, Fuchs A, Yang X, Benner P, Schöpflin R,
Li N, Kinkley S, Römer-Hillmann A, Longinotto J, Heyne S, Czepukojc B, Kessler SM, Kiemer AK, Cadenas C, Arrigoni L, Gasparoni N, Manke T, Pap T, Pospisilik A, Hengstler J, Walter J, Meijsing SH, Chung H-R, Vingron M. 2019. CRUP: a comprehensive framework to predict condition-specific regulatory
units. Genome Biol 20:227

Kröhler T, Kessler SM, Hosseini K, List M, Barghash A, Patial S, Laggai S, Gemperlein K, Haybaeck J, Müller R, Helms V, Schulz MH, Hoppstädter J, Blackshear PJ, Kiemer AK. 2019. The mRNA-binding protein TTP/ZFP36 in hepatocarcinogenesis and hepatocellular carcinoma. Cancers 11:E1754

Dahlem C, Barghash A, Puchas P, Haybaeck J, Kessler SM. 2019. Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer. Int J Mol Sci 20:3204

Kessler SM, Leber B, Hoppstädter J, Golob-Schwarzl N, Hofer EM, Schultheiss CS, Mischinger HJ, Liegl-Atzwanger B, Lackner C, Stiegler P3, Haybaeck J. 2019. Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. PLoS One 14:e0214756

Kessler SM, Hoppstädter J, Hosseini K, Laggai S, Haybaeck J, Kiemer AK. 2019. Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation. J Hepatol 70:175-177

Kessler SM, Hosseini K, Hussein UK, Kim KM, List M, Schultheiss CS, Schulz MH, Laggai S, Jang KY, Kiemer AK. 2019. Hepatocellular carcinoma and nuclear paraspeckles: induction in chemoresistance and prediction for poor survival. Cell Physiol Biochem 52:787-801

Czepukojc B, Abuhaliema A, Barghash A, Tierling S, Simon Y, Körbel C, Cadenas C, van Hul N, Sachinidis A, Hengstler JG, Helms V, Laschke MW, Walter J, Haybaeck J, Leclercq I, Kiemer AK, Kessler SM. IGF2 mRNA binding protein 2 transgenic mice are more prone to develop a ductular reaction and to progress towards cirrhosis. Front Med 6:179

Golob-Schwarzl N, Bettermann K, Mehta AK, Kessler SM, Unterluggauer J, Krassnig S, Kojima K, Chen X, Hoshida Y, Bardeesy NM, Müller H, Svendova V, Schimek MG, Diwoky C, Lipfert A, Mahajan V, Stumptner C, Thüringer A, Fröhlich LF, Stojakovic T, Nilsson KPR, Kolbe T, Rülicke T, Magin TM, Strnad P, Kiemer AK, Moriggl R, Haybaeck J. 2019. High keratin 8/18 ratio predicts aggressive hepatocellular cancer phenotype. Translat Oncol 12:256-268

2018

Levada K, Guldiken N, Vella G, James LP, Haybaeck J, Kessler SM, Kiemer AK, Ott T, Trautwein C, Strnad P. 2018. Hsp72 overexpression protects from liver injury via attenuation of hepatocellular death, oxidative stress and JNK-signaling. J Hepatol 68:966-1005

Dehghani Amirabad A, Ramasamy P, Wierz M, Nordström K, Kessler SM, Schulz MH, Simon M. 2018. Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis. BBA - Mol Basis Dis 1896:3099-3108

2017

Schultheiss CS, Laggei S, Czepukojc B, Hussein UK, List M, Barghash A, Tierling S, Hosseini K, Golob-Schwarzl N, Pokorny J, Hachenthal N, Schulz M, Helms V, Walter J, Zimmer V, Lammert F, Bohle RM, Dandolo L, Haybaeck J, Kiemer AK, Kessler SM. 2017. The long non-conding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma. Cell Stress 1:37-57

Kessler SM, Lederer E, Laggai S, Golob-Schwarzl N, Hosseini K, Petzold J, Schweiger C, Reihs R, Keil M, Hoffmann J, Christian Mayr, Kiesslich T, Pilcher M, Kim KS, Rhee H, Park YN, Lax S, Obrist P, Kiemer AK, Haybaeck J. 2017. IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer. Oncotarget 8:89736-89745

Dembek A, Laggai S, Kessler SM, Czepukojc B, Simon Y, Kiemer AK, Hoppstädter J. 2017. Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation. Immunobiology 222:786-796

2016

Kessler SM, Laggai S, van Wonterghem E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK. 2016. Transient hepatic overexpression of IGF2 induces free cholesterol and lipid droplet formation. Front Physiol 7:147

Barghash A, Golob-Schwarzl N, Helms V, Haybaeck J, Kessler SM. 2016. Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma. Oncotarget 7:49743-49750

Fengler VHI, Macheiner T, Kessler SM, Czepukojc B, Gemperlein K, Müller R, Kiemer AK, Magnes C, Haybaeck J, Lackner C, Sargsyan K. 2016. Susceptibility of different mouse wild type strains to develop diet-induced NAFLD/AFLD-associated liver disease. PLOS One 11:e0155163

Huynh AM, Müller A, Kessler SM, Henrikus S, Hoffmann C, Kiemer AK, Bücker A, Jung G. 2016. Small BODIPY probes for combined dual 19F-MRI and fluorescence imaging. ChemMedChem 1568-1575

2015

Kessler SM, Laggai S, Barghash A, Schultheiß CS, Lederer E, Art M, Helms V, Haybaeck J, Kiemer AK. 2015. IMP2/p62 induces genomic instability and an aggressive HCC phenotype. Cell Death Dis 6:e1894

Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ): a critical factor in macrophage endotoxin tolerance. J Immunol 194:6057-6067

Kessler SM, Barghash A, Laggai S, Helms V, Kiemer AK. 2015. Hepatic hepcidin expression is decreased in cirrhosis and HCC. J Hepatol 62:977-979

Barghash A, Helms V, Kessler SM.2015. Overexpression of IGF2 mRNA-Binding Protein 2 (IMP2/p62) as a feature of basal-like breast cancer correlates with short survival. Scand J Immunol 82:142-143

Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, Kessler SM, Claudel T, Müller M, Mikulits W, Bilban M, Esterbauer H, Eferl R, Haybaeck J, Trauner M, Casanova E. 2015. Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61:613-626

2014

Kessler SM, Laggai S, Barghash A, Helms V, Kiemer AK. 2014. Lipid metabolism signatures in NASH-associated HCC - Letter. Cancer Res 74:2903-2904

Simon Y, Kessler SM, Bohle RM, Haybaeck J, Kiemer AK. 2014. The insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IMP2-2/ IGF2BP2-2 as a promoter of NAFLD and HCC? Gut 63:861-863

Laggai S, Kessler SM, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq IA, Mueller R, Hartmann RW, Haybaeck J, Kiemer AK. 2014. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res 55:1087-1097

Hahn RT, Hoppstädter J, Hirschfelder K, Hachenthal N, Diesel B, Kessler SM, Huwer H, Kiemer AK. 2014. Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation. Atherosclerosis 234:391-400

Simon Y, Kessler SM, Gemperlein K, Bohle RM, Müller R, Haybaeck J, Kiemer AK. 2014. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol 20:17839-178350

Kessler SM, Simon Y, Gemperlein K, Gianmoena K, Cadenas C, Zimmer V, Pokorny J, Barghash A, Helms V, van Rooijen N, Bohle RM, Lammert F, Hengstler JG, Müller R, Haybaeck J, Kiemer AK. 2014. Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma. Int J Mol Sci 15:5762-5773

2013

Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK. 2013. The lgf2-mRNA binding protein p62 in hepatocellular carcinoma: anti-apoptotic action is independent of lgf2/PI3-K signalling. Am J Physiol Gastrointest Liver Physiol 304:G328-G336

Laggai L, Simon Y, Ranssweiler T, Kiemer AK, Kessler SM. 2013. Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. World J Hepatol 304:G328-G336

2011

Tybl E, Shi F-D, Kessler SM, Tierling S, Walter J, Bohle RM, Wieland S, Zhang J, Tan EM, Kiemer AK. 2011. Overexpression of the lgf2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. J Hepatol 54:994-1001

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