Martin Luther University Halle-Wittenberg

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  1. J. Zech, N. Salaymeh, N.H. Hunt, K. Mäder, J. Golenser: Efficient treatment of experimental cerebral malaria by an artemisone-SMEDDS system: impact of application route and dosing frequency. Antimicrobial Agents and Chemotherapy, doi:10.1128/AAC.02106-2    (2021)
  2. E. Lehner, M. Menzel, D. Gündel, S.K. Plontke, K. Mäder, J. Klehm, H. Kielstein, A. Liebau: Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear. Drug Delivery and Translational Research,, (2021).
  3. L.E. de Souza, R. Eckenstaler, F. Syrowatka, M. Beck-Broichsitter, R.A. Benndorf, K. Mäder: Has PEG-PLGA advantages for the delivery of hydrophobic drugs? Risperidone as an example. Journal of Drug Delivery Science and Technology,, (2021).
  4. J. Steiner, R. Alaneed, J. Kressler, K. Mäder: Fatty acid-modified poly(glycerol adipate) microparticles for controlled drug delivery. Journal of Drug Delivery Science and Technology, (2021).
  5. E. Lehner, A. Liebau, F. Syrowatka, W. Knolle, S. K. Plontke, K. Mäder: Novel Biodegradable Round Window Disks for Inner Ear Delivery of Dexamethasone. International Journal of Pharmaceutics, 594, 120180 (2021).


  1. B. Göttel, H. Lucas, F. Syrowatka, W. Knolle, J. Kuntsche, J. Heinzelmann, A. Viestenz, K. Mäder: In situ gelling Amphotericin B Nanofibers: A new Option for the Treatment of Keratomycosis. Front. Bioeng. Biotechnol., 8:600384, (2020).
  2. N. Glücklich, M. Dwivedi, S. Carle, J. Buske, K. Mäder, P.Garidel: An in-depth examination of fatty acid solubility limits in biotherapeutic protein formulations containing polysorbate 20 and polysorbate 80. International Journal of Pharmaceutics, 591, 119934, (2020).
  3. A.K. Noack, H. Lucas, P. Chytil, T. Etrych, K. Mäder, T. Mueller: Intratumoral distribution and pH-dependent drug release of high molecular weight HPMA copolymer drug conjugates strongly depend on specific tumor substructure and microenvironment. International Journal of Molecular Sciences, 21, 6029, (2020).
  4. C. Fink, D. Sun, K. Wagner, M. Schneider, H. Bauer, H. Dolgos, K. Mäder, S. Peters, Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling, Clin. Pharmacol. Ther. 107 (2020) 650–661.
  5. E.F. Busmann, D.G. Martínez, H. Lucas, K. Mäder, Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications, Beilstein J. Nanotechnol. 11 (2020) 213–224.
  6. J. Zech, S. Leisz, B. Göttel, F. Syrowatka, A. Greiner, C. Strauss, W. Knolle, C. Scheller, K. Mäder, Electrospun Nimodipine-loaded fibers for nerve regeneration: Development and in vitro performance, Eur. J. Pharm. Biopharm. 151 (2020) 116–126.
  7. B. Göttel, J.M. de Souza e Silva, C. Santos de Oliveira, F. Syrowatka, M. Fiorentzis, A. Viestenz, A. Viestenz, K. Mäder, Electrospun nanofibers – A promising solid in-situ gelling alternative for ocular drug delivery, Eur. J. Pharm. Biopharm. 146 (2020) 125–132.
  8. M.E. Klein, S. Mauch, M. Rieckmann, D.G. Martínez, G. Hause, M. Noutsias, U. Hofmann, H. Lucas, A. Meister, G. Ramos, H. Loppnow, K. Mäder, Phosphatidylserine (PS) and phosphatidylglycerol (PG) nanodispersions as potential anti-inflammatory therapeutics: Comparison of in vitro activity and impact of pegylation, Nanomedicine Nanotechnology, Biol. Med. 23 (2020) 102096.
  9. J.L. Schmid, M. Kirchberg, S. Sarembe, A. Kiesow, A. Sculean, K. Mäder, M. Buchholz, S. Eick, In vitro evaluation of antimicrobial activity of minocycline formulations for topical application in periodontal therapy, Pharmaceutics. 12 (2020).
  10. R. Alaneed, T. Hauenschild, K. Mäder, M. Pietzsch, J. Kressler, Conjugation of Amine-Functionalized Polyesters With Dimethylcasein Using Microbial Transglutaminase, J. Pharm. Sci. 109 (2020) 981–991.
  11. P. Modicano, R. Neumann, M. Schüller, J. Holthof, F.L. Kyrilis, F. Hamdi, P.L. Kastritis, K. Mäder, L. Ann Dailey, Enhanced optical imaging properties of lipid nanocapsules as vehicles for fluorescent conjugated polymers, Eur. J. Pharm. Biopharm. 154 (2020) 297–308.
  12. M.E. Klein, M. Rieckmann, H. Lucas, A. Meister, H. Loppnow, K. Mäder, Phosphatidylserine (PS) and phosphatidylglycerol (PG) enriched mixed micelles (MM): A new nano-drug delivery system with anti-inflammatory potential?, Eur. J. Pharm. Sci. 152 (2020) 105451.
  13. N. Sanaeifar, K. Mäder, D. Hinderberger, Nanoscopic Characterization of Stearic Acid Release from Bovine Serum Albumin Hydrogels, Macromol. Biosci. (2020) 2000126.
  14. C. Fink, M. Lecomte, L. Badolo, K. Wagner, K. Mäder, S.A. Peters, Identification of solubility-limited absorption of oral anticancer drugs using PBPK modeling based on rat PK and its relevance to human, Eur. J. Pharm. Sci. 152 (2020) 105431.
  15. J. Zech, D. Gold, N. Salaymeh, N.C. Sasson, I. Rabinowitch, J. Golenser, K. Mäder, Oral Administration of Artemisone for the Treatment of Schistosomiasis: Formulation Challenges and In Vivo Efficacy, Pharmaceutics. 12 (2020) 509.
  16. D. Gerloff, J. Lützkendorf, R.K.C. Moritz, T. Wersig, K. Mäder, L.P. Müller, C. Sunderkötter, Melanoma-Derived Exosomal miR-125b-5p Educates Tumor Associated Macrophages (TAMs) by Targeting Lysosomal Acid Lipase A (LIPA), Cancers (Basel). 12 (2020) 464.
  17. M. Kirchberg, S. Eick, M. Buchholz, F. Rosche, A. Kiesow, S. Sarembe, K. Mäder, Controlled release minocycline-lipid-complex extrudates for the therapy of periodontitis with enhanced flexibility, Int. J. Pharm. 586 (2020) 119578.
  18. C. Auch, C. Jede, M. Harms, C. Wagner, K. Mäder, Impact of amorphization and GI physiology on supersaturation and precipitation of poorly soluble weakly basic drugs using a small-scale in vitro transfer model, Int. J. Pharm. 574 (2020) 118917.
  19. S. Leisz, M.-L. Trutschel, K. Mäder, C. Scheller, C. Strauss, S. Simmermacher, Tabotamp®, Respectively, Surgicel®, Increases the Cell Death of Neuronal and Glial Cells In Vitro, Materials (Basel). 13 (2020) 2453.
  20. C. Zlomke, J. Albrecht, K. Mäder, Nicardipine Loaded Solid Phospholipid Extrudates for the Prevention of Cerebral Vasospasms: In Vitro Characterization, Pharmaceutics. 12 (2020) 817.
  21. J. Zech, M. Mader, D. Gündel, H. Metz, A. Odparlik, S. Agarwal, K. Mäder, A. Greiner, Noninvasive characterization (EPR, μCT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery, Int. J. Pharm. X. 2 (2020) 100055.
  22. Y.A. Brito Barrera, G. Hause, M. Menzel, C.E.H. Schmelzer, E. Lehner, K. Mäder, C. Wölk, T. Groth, Engineering osteogenic microenvironments by combination of multilayers from collagen type I and chondroitin sulfate with novel cationic liposomes, Mater. Today Bio. 7 (2020) 100071.


  1. E. Lehner, D. Gündel, A. Liebau, S. Plontke, K. Mäder: Intracochlear PLGA based implants for dexamethasone release: challenges and solutions. International Journal of Pharmaceutics X, (2019).
  2. M.H. Bilal, R. Alaneed, J. Steiner, K. Mäder, M. Pietzsch, J. Kressler: Multiple grafting to enzymatically synthesized polyesters. Methods in Enzymology,, (2019).
  3. J. Strätz, A. Liedmann, M.L. Trutschel, K. Mäder, T. Groth, S. Fischer: Development of hydrogels based on oxidized cellulose sulfates an carboxymethyl chitosan. Cellulose,  596-6 (2019).
  4. C. Auch, M. Harms, Y. Golitsyn, D. Reichert, K. Mäder: Miniaturized measurement of drug-polymer  interactions via viscosity increase for polymer selection in amorphous  solid dispersions. Molecular Pharmaceutics, DOI: 10.1021/acs.molpharmaceut.9b00186 (2019).
  5. C.  Zlomke, M. Barth, K. Mäder: Polymer degradation induced drug  precipitation in PLGA implants – why less is sometimes more. European  Journal of Pharmaceutics and Biopharmaceutics, 139, 142-152, (2019).
  6. M.  Riehl, M. Harms, B, Göttel, H. Kubas, D. Schiroky, K. Mäder: Acid  induced degradation of widely used NIR dye DiR causes hypsochromic shift  in fluorescence properties. European Journal of Pharmaceutical  Sciences, 132, 27-33, (2019).
  7. C. Auch, M. Harms, Karsten  Mäder: How changes in molecular weight and PDI of a polymer in amorphous  solid dispersions impact dissolution performance. International Journal  of Pharmaceutics, 556, 372-382 (2019).
  8. L. Lampp, O.Y. Rogozhnikova, D.V. Trukhin, V.M. Tormyshev, M.K. Bowman, N. Devasahayam, M.C. Krishna, K. Mäder, P. Imming: A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR. Free Radical Biology and Medicine, 130, 120–127 (2019).
  9. M. Kirchberg, S. Eick, M. Buchholz, A. Kiesow, S. Sarembe, K. Mäder, Extrudates of lipophilic tetracycline complexes: A new option for periodontitis therapy, Int. J. Pharm. 572 (2019) 118794.
  10. C. Janich, A. Friedmann, J.M. de S. e Silva, C.S. de Oliveira, L.E. de Souza, D. Rujescu, C. Hildebrandt, M. Beck-Broichsitter, C.E.H. Schmelzer, K. Mäder, Risperidone-loaded PLGA–lipid particles with improved release kinetics: Manufacturing and detailed characterization by electron microscopy and nano-CT, Pharmaceutics. 11 (2019).


  1. C. Auch, M. Harms, K. Mäder: Melt-based screening method with improved predictability regarding polymer selection for amorphous solid dispersions. European Journal of Pharmaceutical Sciences, 124, 339-348 (2018)
  2. T. Wersig, R. Krombholz, C. Janich, A. Meister, J. Kressler, K. Mäder:
    Indomethacin functionalised poly(glycerol adipate) nanospheres as promising candidates for modified drug release.
    Journal of Pharmaceutical Sciences, 123, 350-361 (2018)
  3. J.J. Stelzner, M. Behrens, S.E. Behrens, K. Mäder:
    Squalene  Containing Solid Lipid Nanoparticles, a Promising Adjuvant System for  the Immunisation with Yeast Vaccines. Vaccine, 36, 2314-2320 (2018).
  4. K.  Mäder, E. Lehner, A. Liebau, S., K. Plontke: Controlled drug release to  the inner ear: concepts, materials, mechanisms and performance. Hearing Research,    (2018).
  5. M. Riehl, M. Harms, H. Lucas, T. Ebensen, C.A. Guzmán, K. Mäder:
    Dual dye in-vivo imaging of differentially charged PLGA carriers reveals antigen-depot effect,
    leading to improved immune responses in preclinical models.
    European Journal of Pharmaceutical Sciences, 117, 88-97, (2018).
  6. V. Weiss, H. Lucas, T. Mueller, P. Chytil, T. Etrych, T. Naolou, J. Kressler, K. Mäder:
    Intended and Unintended Targeting of Polymeric Nanocarriers:
    The Case of Modified Poly(glycerol adipate) Nanoparticles.
    Macromolecular Bioscience, DOI:10.10002/mabi.20   1700240 (2018).


  1. M. Riehl, M. Harms, A. Hanefeld, R.B. Baleeiro, P. Walden, K. Mäder:
    Combining R-DOTAP and a particulate antigen delivery platform to trigger dendritic cell activation: formulation development and in-vitro interaction studies.
    International Journal of Pharmaceutics, 532, 37–46, (2017).
  2. D. Bär, H. Debus, C. Grune, S. Tosch, W. Fischer, K. Mäder, P. Imming:
    Improving the drug release of Naproxen Sodium tablets
    by preparing granules and tablets with a preferred mixing ratio of hydrates
    European Journal of Pharmaceutics and Biopharmaceutics 121, 90–96, (2017).
  3. T. Wersig, M.C. Hacker, J. Kressler and K. Mäder:
    Poly(glycerol adipate) – Indomethacin Drug Conjugates – Synthesis and in vitro Characterization.
    International Journal of Pharmaceutics, 531
    , 225-234, (2017).
  4. Y.K. Demir, A.Ü. Metin, B. Şatıroğlu, M.E. Solmaz, V. Kayser, K. Mäder:
    Poly (methyl vinyl ether-co-maleic acid) – Pectin Based Hydrogel-FormingSystems:
    Gel, Film, and Microneedles,
    European Journal of Pharmaceutics and Biopharmaceutics, 117, 182–194 (2017).
  5. M.H. Bilal, H. Hussain, M. Prehm, U. Baumeister, A. Meister, G. Hause, K. Busse, K. Mäder, J. Kressler:
    Synthesis of Poly(glycerol adipate)-g-Oleate and its Ternary Phase Diagram
    with Glycerol Monooleate and Water.
    European Polymer Journal, 91, 162–175 (2017).
  6. M. Elewa, N.Maltar-Strmečki, M.M. Said, H.A. El Shihawy, M. El-Sadek, J. Frank,
    S. Drescher, M. Drescher, K. Mäder, D. Hinderberger, P. Imming:
    Synthesis and EPR –spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid
    radical (PTMTC) and its 13C labelled analogue (13C-PTMTC).
    Physical Chemistry Chemical Physics, 19, 6688-6697 (2017).


  1. M. Heider, G. Hause, K. Mäder:
    Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility
    of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN).
    European Journal of Pharmaceutics and Biopharmaceutics, 109
    , 194-205 (2016).
  2. A. Mante, M. Heider, C. Zlomke, K. Mäder:
    PLGA nanoparticles for peroral delivery: How important is pancreatic digestion and can we control it?
    European Journal of Pharmaceutics and Biopharmaceutics, 108
    , 32-40 (2016).
  3. R. Pola, A.-K. Heinrich, T. Mueller, L. Kostka, K. Mäder, M. Pechar, T. Etrych:
    Passive tumor targeting of polymer therapeutics: In vivo imaging of both the polymer carrier
    and the enzymatically cleavable drug model.
    Macromolecular Bioscience. 6, 1577-1582 (2016).
  4. T. Etrych, H. Lucas, O. Janouskova, P. Chytil, T. Müller, K. Mäder:
    Fluorescence Optical Imaging in anticancer drug delivery.
    Journal of Controlled Release, 226, 168-181, (2016)
  5. A.-K. Heinrich, H. Lucas, L. Schindler, P. Chytil, T. Etrych, K. Mäder, T. Mueller
    Improved tumor specific drug accumulation by polymer therapeutics with
    pH-sensitive drug release overcomes chemotherapy resistance.
    Molecular Cancer Therapeutics, doi:10.1158/1535-7163.MCT-15-0824,    (2016)
  6. M. Studenovsky, A.-K. Heinrich, H. Lucas, T. Mueller, K. Mäder, T. Etrych:
    Dual fluorescent HPMA-based conjugates for passive tumor targeting with
    reduction-sensitive drug release: Proof of the concept, tumor accumulation and biodistribution.
    Journal of Bioactive and Compatible Polymers, doi:10.1177/0883911515618975,    (2016)
  7. M. Bachmann, M. Wensch-Dorendorf, K. Mäder, M. Bulang, A. Zeyner:
    Preparation of synthetic alkane waxes and investigations on their suitability
    for application as dietary markers in farm animals.
    Livestock Science, 185,110–116, (2016)
  8. Y. Yang, A. Köwitsch, N. Ma, K. Mäder, I. Pashkuleva, R.L. Reis, T. Groth:
    Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion.
    Journal of Bioactive and Compatible Polymers, accepted, (2016)


  1. J. Frank, D. Gündel, S. Drescher, O. Thews, K. Mäder:
    Injectable LiNc-BuO loaded microspheres as in vivo EPR oxygen sensors
    after co-implantation with tumor cells.
    Free Radical Biology & Medicine, 89, 741–749 (2015).
  2. J. Walldorf, M. Hermann, M. Porzner, S. Pohl, H. Metz, K. Mäder, A. Zipprich, B. Christ, T. Seufferlein:
    In-vivo monitoring of acute DSS-colitis using colonoscopy, high resolution ultrasonography
    and bench-top magnetic resonance imaging in mice.
    European Radiology, (2015)
  3. J. Frank, M. Elewa, M. Said, H. Elshihawy, M. El-Sadek, D. Mueller, A. Meister, G. Hause, S. Drescher, H. Metz, P. Imming, K. Mäder:
    Synthesis, characterization, and nanoencapsulation of tetrathiatriarylmethyl and tetrachlorotriarylmethyl (trityl) radical derivatives. A study to advance their applicability as in vivo EPR oxygen sensors.
    Journal of Organic Chemistry, 80, 6754–6766, (2015).
  4. M. Riehl, M. Harms, A. Hanefeld, K. Mäder:
    Investigation of the stabilizer elimination during the washing step of charged PLGA microparticles
    utilizing a novel HPLC-UV-ELSD method.
    European Journal of Pharmaceutics and Biopharmaceutics, 94, 468–472, (2015)
  5. T.H. Hassan, K. Mäder:
    Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation
    and in vitro digestion.
    International Journal of Pharmaceutics
    486, 77-87, (2015)
  6. M.P. Do, C. Neut, H. Metz, E. Delcourt, J. Siepmann, K. Mäder, F. Siepmann:
    Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment.
    European Journal of Pharmaceutics and Biopharmaceutics , 94, 273–283, (2015)
  7. M.P.Do, C. Neut, H. Metz, E. Delcourt, K. Mäder, J. Siepmann, F. Siepmann:
    In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance.
    International Journal of Pharmaceutics, 486, 38-51, (2015)
  8. A. Belete, H. Metz, T. Mueller, K. Maeder:
    Benchtop MRI for pharmacokinetic evaluation of two aqueous-based nano-scaled formulations of oleic acid stabilized magnetite nanocrystals.
    Drug Development and Industrial Pharmacy, 41 (3), 406-414, (2015)


  1. B. Schreier, S. Rabe, S. Winter, S. Ruhs, S. Mildenberger, B. Schneider, M. Sibilia, M. Gotthardt,
    S. Kempe, K. Mäder, C. Grossmann, M. Gekle:
    Moderate inappropriately high aldosterone/NaCl constellation in mice:
    Cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.
    Scientific Reports, 4, 7430, DOI: 10.1038/srep07430 (2014).
  2. F. Eisenächer, G. Garbacz, K. Mäder:
    Physiological relevant in vitro evaluation of polymer coats for gastroretentive floating tablets.
    European Journal of Pharmaceutics and Biopharmaceutics, 88, 778–786, (2014).
  3. T.H. Hassan, H. Metz, K. Mäder:
    Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: Development and characterization.
    International Journal of Pharmaceutics, 477, 506–518, (2014).
  4. A. Köwitsch, J. Abreu, A. Chhalotre, M. Hielscher, S. Fischer, K. Mäder. T. Groth:
    Synthesis of thiolated glycosaminoglycans and grafting to solid surfaces.
    Carbohydrate Polymers, 114, 344-351, (2014).
  5. S.K. Plontke, A. Glien,T. Rahne, K. Mäder, A.N. Salt:
    Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic
    sudden sensorineural hearing loss.
    Otology & Neurotology, accepted, (2014).
  6. A. Schädlich, S. Kempe, K. Mäder:
    Non-invasive in vivo characterization of microclimate pH inside in situ forming PLGA implants using multispectral fluorescence imaging.
    Journal of Controlled Release, 179, 52–62, (2014).
  7. Y. Yang, H. Tang, A. Köwitsch, K. Mäder, G. Hause, J. Ulrich,T. Groth:
    Novel mineralized heparin–gelatin nanoparticles for potential application in tissue engineering of bone
    Journal of Material Science: Materials in Medicine, 25, 669–680, (2014).


  1. S. Kempe, B. Schreier, S. Ruhs, I. Wollert, M. B. Teixeira, M. Gekle, K. Mäder:
    Development and Noninvasive Characterization of Hormone Releasing In Situ Forming Implants.
    Macromolecular Symposia, 334, 98-105 (2013).
  2. P. Chytil, S. Hoffmann, L. Schindler, L. Kostka, K. Ulbrich, H. Caysa, T. Mueller, K. Mäder and
    T. Etrych: Dual Fluorescent HPMA Copolymers for Passive Tumor Targeting with pH-Sensitive Drug Release: Impact of Release Rate on Biodistribution.
    Journal of Controlled Release, accepted DOI 10.1016/j.jconrel.2013.05.008 (2013).
  3. A. Hill, S. Geißler, M. Meyring, S. Hecht, M. Weigandt and K. Mäder:
    In-Vitro-In-Vivo evaluation of nanosuspension release from subcutaneously implantable osmotic pumps.
    International Journal of Pharmaceutics, 451, 57– 66 (2013).
  4. C. Kutza, H. Metz, J. Kutza, F. Syrowatka, K. Mäder:
    Toward a detailed characterization of oil adsorbates as "solid liquids”.
    European Journal of Pharmaceutics and Biopharmaceutics, 84
    , 172-182 (2013).
  5. S. Hoffmann, H. Caysa, J. Kuntsche, P. Kreideweiß, A. Leimert, T. Müller, K. Mäder:
    Carbohydrates for Passive Tumor Targeting: In Vivo Studies and Size Distribution Characterisation
    In Vitro and In Vivo Studies. Carbohydrate Polymers, 95
    , 404-413 (2013).
  6. A. Hill, S. Breyer, S. Geissler, W. Mier, U. Haberkorn, M. Weigandt, K. Mäder:
    How do in-vitro release profiles of nanosuspensions from Alzet® pumps correspond to the in-vivo situation? A case study on radiolabeled fenofibrate. Journal of Controlled Release, 168, 77-87 (2013).
  7. F. Tenambergen, C. H. Maruiama, K. Mäder:
    Dual asymmetric centrifugation as an alternative preparation method for parenteral fat emulsions
    in preformulation development.
    International Journal of Pharmaceutics, 447, 31–37 (2013).
  8. V.M. Weiss, T. Naolou, T. Groth, J. Kressler, K. Mäder:
    In vitro toxicity of stearoyl-poly(glycerol adipate) nanoparticles.
    J. Appl. Biomater. Function Mater. , 10
    (3), 163-169 (2013).
  9. A. Belete, K. Maeder:
    Novel aqueous nano-scaled formulations of oleic acid stabilized
    hydrophobic superparamagnetic iron oxide nanocrystals.
    Drug Development and Industrial Pharmacy, 39 (2), 186-196 (2013).


  1. W. Mehnert, K. Mäder:
    Solid lipid nanoparticles. Production, characterization and applications.
    Advanced Drug Delivery Reviews
    64 (Suppl.), 83-101 (2012).
  2. H. Caysa, S. Hoffmann, J. Luetzkendorf, L.P. Mueller, S. Unverzagt, K. Mäder, T. Mueller:
    Monitoring of xenograft tumor growth and response to chemotherapy by non-invasive in vivo multispectral fluorescence imaging. PloS ONE
    , 7(10):e47927, (2012).
  3. A. Noack, K. Mäder:
    In vitro digestion of curcuminoid-loaded lipid nanoparticles.
    Journal of Nanoparticle Research,
    14 (9), art. no. 1113 (2012).
  4. S. Kempe, K. Mäder:
    In situ forming implants - an attractive formulation principle for parenteral depot formulations.
    Journal of Controlled Release
    161, 668-679 (2012).
  5. A. Schädlich, S. Hoffmann, T. Mueller, H. Caysa, C. Rose, A. Göpferich, J. Li, J. Kuntsche, K. Mäder:
    Accumulation of nanocarriers in the ovary: a neglected toxicity risk?
    Journal of Controlled Release
    160, 105–112 (2012).
  6. S. Hoffmann, L. Vystrcilova, K. Ulbrich, T. Etrych, H. Caysa, T. Mueller, K. Mäder:
    Dual Fluorescent HPMA Copolymers for Passive Tumour Targeting with pH-Sensitive Drug Release: Synthesis and Characterisation of Distribution and Tumour Accumulation in Mice by Noninvasive Multispectral Optical Imaging. Biomacromolecules,
    13, 652–663 (012).
  7. A. Hill, S. Geißler, M. Weigandt, K. Mäder:
    Controlled delivery of nanosuspensions from osmotic pumps: Zero order and non-zero order kinetics.
    Journal of Controlled Release, 158,
    403-412 (2012).
  8. V.M. Weiss, T. Naolou, G. Hause, J. Kuntsche, J. Kressler, K. Mäder:
    Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. Journal of Controlled Release
    , 158, 156–164 (2012).
  9. G.N. Kaluderović, A. Dietrich, H. Kommera, J. Kuntsche, K. Mäder, T. Mueller, R. Paschke:
    Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II).
    European Journal of Medicinal Chemistry
    , 54, 567-572 (2012).
  10. A. Belete, K. Maeder:
    Novel aqueous nano-scaled formulations of oleic acid stabilized hydrophobic superparamagnetic iron oxide nanocrystals.
    Drug Development and Industrial Pharmacy
    , doi:10.3109/03639045.2012.665927,    (2012).
  11. M. Betz, B. Steiner, M. Schantz, J. Oidtmann, K.Mäder, E. Richling, U. Kulozik:
    Antioxidant capacity of bilberry extract microencapsulated in whey protein hydrogels, Food Research International
    , 47, 51–57 (2012).
  12. H.M. Abdel-Mageed, H.M. El-Laithy, L.G. Mahrand, A.S. Fahmy, K. Mäder, S.A. Mohamed:
    Development of novel flexible sugar ester vesicles as carrier systems for the antioxidant enzyme catalase for wound healing applications. Process Biochemistry
    47, 1155–1162, (2012).
  13. A. Noack, G. Hause, K. Mäder:
    Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles International Journal of Pharmaceutics
    , 423, 440– 451 (2012).
  14. J. Oidtmann, M. Schantz, Mäder, K., M. Baum, S. Berg, M. Betz, U. Kulozik, S. Leick, H. Rehage, K. Schwarz, E. Richling:
    Preparation and comparative release characteristics of three anthocyanin encapsulation systems.
    Journal of Agricultural and Food Chemistry,
    60, 844–851 (2012).
  15. V.M. Weiss, T. Naolou, E. Amado, K. Busse, K. Mäder, J. Kressler:
    Formation of Structured Polygonal Nanoparticles by Phase-separated Comb-like Polymers.
    Macromolecular Rapid Communications,
    33, 35−40 (2012).


  1. A. Schädlich, H. Caysa, T. Mueller, F. Tenambergen, C. Rose, A. Göpferich, J. Kuntsche, K. Mäder:
    Tumor accumulation of NIR fluorescent PEG-PLA nanoparticles: Impact of particle size and human xenograft tumor model.
    ACS Nano 5, 8710–8720 (2011).
  2. A. Schädlich, T. Naolou, E. Amado, R. Schöps, J. Kressler, K. Mäder:
    Non-invasive in vivo monitoring of the bio-fate of 195 kDa poly(vinyl alcohol) by multispectral fluorescence imaging.
    Biomacromolecules, 12 ,3674–3683, (2011).
  3. A. Köwitsch, Y. Yang, N. Ma, J. Kuntsche, K. Mäder, T. Groth:
    Bioactivity of immobilized hyaluronic acid derivatives regarding protein adsorption and cell adhesion.
    Biotechnology and Applied Biochemistry, 58, 376–389, (2011).
  4. T. Seidenberger, J. Siepmann, H. Bley, K. Maeder, F. Siepmann
    Simultaneous controlled Vitamin release from multiparticulates: theory and experiment.
    International Journal of Pharmaceutics, 412, 68-76 (2011).
  5. H. Caysa, H. Metz, K. Mäder, T. Mueller:
    Application of Benchtop-magnetic resonance imaging in a nude mouse tumor model.
    Journal of Experimental & Clinical Cancer Research, 30:69, (2011).
  6. A. Schädlich, C. Rose, J. Kuntsche, H. Caysa, T. Mueller, A. Göpferich, K. Mäder:
    How stealthy are PEG-PLGA nanoparticles? A NIR in vivo study combined with detailed size measurements.
    Pharmaceutical Research 28, 1995-2007, (2011).
  7. A. Besheer, H. Caysa, H. Metz, T. Mueller, J. Kressler, K. Mäder:
    Benchtop-MRI for in vivo imaging using a macromolecular contrast agent based on hydroxyethyl starch (HES).
    International Journal of Pharmaceutics, 417, 196-203, (2011).
  8. F. Eisenächer, A. Schädlich, K. Mäder:
    Monitoring of internal pH gradients within multi-layer tablets by optical methods and EPR imaging.
    International Journal of Pharmaceutics, 417, 204-215, (2011).
  9. C. Lehermayr, H-C Mahler, K. Mäder, S. Fischer:
    Assessment of net charge and protein-protein interactions of different monoclonal antibodies.
    Journal of Pharmaceutical Sciences, 100, 2551–2562, (2011).
  10. M. Bastrop, A. Meister, H. Metz, S. Drescher, B. Dobner, K. Mäder, A. Blume:
    Water Dynamics in Bolaamphiphile Hydrogels Investigated by 1H-NMR Relaxometry and Diffusometry.
    Journal of Physical Chemistry, 115, 14–22 (2011).


  1. A. Lochmann, H. Nitzsche, S. von Einem, E. Schwarz, K. Mäder:
    The influence of covalently linked and free polyethylene glycol
    on the structural and release properties of rhBMP-2 loaded microspheres.
    Journal of Controlled Release 147, 92-100 (2010).
  2. A. Schädlich, Y. Jiang, J. Kressler, K. Mäder
    Tracking the in vivo fate of high molar mass poly (vinyl alcohol) using
    multispectral fluorescence in vivo imaging
    Controlled Release Society (CRS) Newsletter, Scientifically Speaking Volume 27, Number 2, 2010
  3. H. Nitzsche, A. Lochmann, H. Metz, A. Hauser, F. Syrowatka, E. Hempel, T. Müller, T. Thurn-Albrecht, K. Mäder: Fabrication and Characterization of a Biomimetic Composite Scaffold for Bone Defect Repair, Journal of Biomedical Materials Research: Part A, 94, 298-307 (2010).
  4. Y. Jiang, A. Schädlich, E. Amado, C. Weis, E. Odermatt, K. Mäder, J. Kressler:In vivo Studies on Intraperitoneally Administrated Poly(vinyl alcohol. Journal of Biomedical Materials Research: Part B - Applied Biomaterials Volume 93B, Issue 1, pages 275–284, April 2010
  5. C. Preetz, A. Hause, G. Hause, A. Kramer, K. Mäder:Application of Atomic Force Microscopy and Ultrasonic Resonator Technology on nanoscale: Distinction of nanoemulsions from nanocapsules. European Journal of Pharmaceutical Sciences, 39, 141-151 (2010).
  6. M. Knörgen, R.P. Spielmann, A. Abdalla, H. Metz, K. Mäder:Non-invasive MRI detection of individual pellets in the human stomach.European Journal of Pharmaceutics and Biopharmaceutics, 74, 120-125(2010).
  7. S. Kempe, H. Metz, K. Mäder: Application of Electron Paramagnetic Resonance (EPR) - Spectroscopy and Imaging in drug delivery research - chances and challenges.European Journal of Pharmaceutics and Biopharmaceutics, 74, 55-66 (2010).
  8. S. Kempe, H. Metz, K. Mäder:Noninvasive in vivo evaluation of in situ forming implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy. European Journal of Pharmaceutics and Biopharmaceutics, 74, 102-108 (2010).


  1. H.-C. Mahler, F. Senner, K. Mäder, R. Mueller: Surface activity of a monoclonal antibody. Journal of Pharmaceutical Sciences, 98, 4525-4533(2009).
  2. A. Besheer, T.C. Hertel, J. Kressler, K. Mäder, M. Pietzsch:Enzymatically-catalyzed HES-conjugation using microbial transglutaminase: Proof of feasibility.Journal of Pharmaceutical Sciences 98,
    4420-4428 (2009).
  3. H. Nitzsche, H. Metz, A. Lochmann, A. Bernstein, G. Hause, T. Groth, K. MÄder:Characterization of Scaffolds for Tissue Engineering by Benchtop-MRI, Tissue EngineeringPart C: Methods 15, 513-521 (2009).
  4. R. Mueller, A. Karle, A. Vogt, A. Ross, K. Mäder, H.-C.Mahler:Evaluation of the immuno-stimulatory potential of stopper extractables and leachables by using dendritic cells as read-out. Journal of Pharmaceutical Sciences 98, 3548-3561 (2009).
  5. S. Ensslin, K.P. Moll, T. Haefele-Racina, K. Mäder:Safety and robustness of coated pellets: self-healing film properties and storage stability. Pharmaceutical Research 26, 1534-1543 (2009)
  6. A-K. Kirchherr, A. Briel, K. Mäder:Stabilization of Indocyanine Green by Encapsulation within Micellar Systems.Molecular Pharmaceutics, 6(2),  480-491 (2009).
  7. A. Besheer, J. Vogel, D. Glanz, J. Kressler, T. Groth, K. Mäder:Characterization of PLGA nanospheres stabilized with amphiphilic polymers - hydrophobically-modified hydroxyethyl starch vs. Pluronics. Molecular Pharmaceutics, 6(2),  407-415, (2009).
  8. S. Ensslin, K.P. Moll, H. Metz, M. Otz, K. Mäder: Modulating pH independent release from coated pellets – effect of coating composition on solubilization processes and drug release. European Journal of Pharmaceutics and Biopharmaceutics 72, 111-118 (2009).
  9. A. Abdalla, K. Mäder:ESR studies on the influence of physiological dissolution and digestion media on the lipid phase characteristics of SEDDS and SEDDS pellets. International Journal of Pharmaceutics,367, 29-36 (2009).
  10. M. Bastrop, A. Meister, H. Metz, S. Drescher, B. Dobner, K. Mäder, A. Blume:The motional dynamics in bolaamphiphile nanofibers and micellar aggregates: An ESR spin probe study.Journal of Physical Chemistry B,113, 574-582 (2009).
  11. V. Malaterre, H. Metz, J. Ogorka, R. Gurny, N. Loggia, K. Mäder:Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems.Journal of Controlled Release133, 31-36 (2009).


  1. A. Abdalla, S. Klein, K. Mäder:
    A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: characterization, dissolution, in vitro digestion and incorporation into solid pellets. European Journal of Pharmaceutical Sciences 35, 457–464 (2008).
  2. H. Metz, K. Mäder:
    Benchtop-NMR and MRI - a new analytical tool in drug delivery research. International Journal of Pharmaceutics 364, 170–175 (2008).
  3. S. Ullrich, H. Metz, K.Mäder:
    Sucrose ester Nanodispersions: Microviscosity and Viscoelastic Properties.
    European Journal of Pharmaceutics and Biopharmaceutics 70, 550–555 (2008).
  4. S. Kempe, H. Metz, K. Mäder:
    Do in situ forming PLG/NMP implants behave similar in vitro and in vivo? A non-invasive and quantititative EPR investigation on the mechanisms of the implant formation process.
    Journal of Controlled Release, 130, 220–225 (2008).
  5. J. Lohrke, A. Briel, K. Mäder:
    Characterization of Superparamagnetic Iron Oxide Nanoparticles by Asymmetrical Flow Field-Flow-Fractionation.
    Nanomedicine, 3, 437-452 (2008).
  6. C. Preetz, A. Rübe, I. Reiche, G. Hause, K. Mäder:
    Preparation and Characterization of Biocompatible Oil- loaded Polyelectrolyte Nanocapsules.
    Nanomedicine: Nanotechnology, Biology, and Medicine. 4, 106–114 (2008).
  7. S. Ensslin, K. P. Moll, K. Paulus, K. Mäder:
    New insight into modified release pellets – internal structure and drug release mechanism.
    Journal of Controlled Release, 128, 149–156 (2008).
  8. C. Augsten, M.A. Kiselev, R. Gehrke, G. Hause, K. Mäder:
    A Detailed Analysis of Biodegradable Nanospheres by Different Techniques – A Combined Approach to Detect Particle Sizes and Size Distributions.
    Journal of Pharmaceutical and Biomedical Analysis, 47, 95–102 (2008).
  9. S. Strübing, T. Abboud, R. Vidor Contri, H. Metz, K. Mäder:
    New insights on Polyvinylacetate based coated floating tablets: Characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength.
    European Journal of Pharmaceutics and Biopharmaceutics, 69, 708–717 (2008).
  10. S. Strübing, H. Metz, K. Mäder:
    Characterization of polyvinyl acetate based floating matrix tablets.
    Journal of Controlled Release 126, 149–155 (2008).
  11. C. Augsten, W. Knolle, K. Mäder:
    Characterizing the Influence of Electron Irradiation on Scleroglucan.
    Carbohydrate Polymers, 72 707–718 (2008).
  12. C. Augsten, K. Mäder:
    Characterizing Molar Mass Distributions and Molecule Structures of Different Chitosans using Asymmetrical Flow Field-Flow Fractionation combined with Multi-Angle Light Scattering.
    International Journal of Pharmaceutics, 351, 23–30 (2008).
  13. A. Szepes, Z. Makai, C. Blümer, K. Mäder, P. Kása jr., P. Szabó-Révész:
    Formulation of starch based hydrogels using isostatic ultra high pressure.
    Carbohydrate Polymers, 72, 571-578 (2008).
  14. S. Kempe, H. Metz, M. Bastrop, A. Hvilsom, R.V. Contri, K. Mäder:
    Characterization of thermosensitive chitosan-based hydrogels by Rheology and Electron Paramagnetic Resonance Spectroscopy.
    European Journal of Pharmaceutics and Biopharmaceutics 68, 26–33 (2008).


  1. S. Mao, C. Augsten, K. Mäder, T. Kissel:
    Characterization of chitosan and its derivatives using asymmetrical Flow Field-Flow-Fractionation: a comparison with traditional methods.
    Journal of Pharmaceutical and Biomedical Analysis, 45, 736–741 (2007)
  2. S. Strübing, H. Metz, F. Syrowatka, K. Mäder:
    Monitoring of dissolution induced changes in film coat composition by 1H NMR spectroscopy and SEM.
    Journal of Controlled Release 119, 190–196 (2007).
  3. A. Beesher, K. Mäder, S. Kaiser, J. Kressler, C. Weis, E.K. Odermatt:
    Tracking of Urinary Excretion of High Molar Mass Poly(vinyl alcohol).
    Journal of Biomedical Materials Research: Part B - Applied Biomaterials 82B, 383-389 (2007).
  4. A. Abdalla, K. Mäder:
    Preparation and characterization of a self-emulsifying pellet formulation.
    European Journal of Pharmaceutics and Biopharmaceutics, 66, 220–226, (2007).
  5. A. Besheer,G. Hause, J. Kressler,K. Mäder:
    Hydrophobically Modified Hydroxyethyl Starch: Synthesis, Characterization, and Aqueous Self-Assembly into Nano-Sized Polymeric Micelles and Vesicles.
    Biomacromolecules 8, 359-367 (2007), (Erratum Biomacr. 8, 2045 (2007).
  6. S. Strübing, H. Metz, K. Mäder:
    Mechanistic analysis of drug release from tablets with membrane controlled drug delivery.
    European Journal of Pharmaceutics and Biopharmaceutics, 66, 113–119 (2007).


  1. E. Amado, C. Augsten, K. Mäder, A. Blume, J. Kressler:
    Amphiphilic Water Soluble Triblock Copolymers Based on Poly(2,3-dihydroxypropyl methacrylate) and Poly(propylene oxide): Synthesis by Atom Transfer Radical Polymerization and Micellization in Aqueous Solutions.
    Macromolecules, 39, 9486-9496 (2006).
  2. C. Augsten, K. Mäder:
    Asymmetrische Fluß/Feld-Fluß-Fraktionierung in Verbindung mit Mehrwinkel-Lichtstreudetektion. Eine neue bedeutende Methode der pharmazeutischen Analytik
    Pharmazeutische Industrie, 68,1412-1419 (2006).
  3. A. Rübe, S. Klein, K. Mäder:
    Monitoring of in vitro fat digestion by Electron Paramagnetic Resonance Spectroscopy.
    Pharmaceutical Research, 23, 2024-2029 (2006).
  4. A. Besheer, K.M. Wood, N.A. Peppas, K. Mäder:
    Loading and Mobility of Spin-Labeled Insulin in Physiologically Responsive Complexation Hydrogels Intended for Oral Administration.
    Journal of Controlled Release 111, 73–80 (2006).


  1. C. Lemarchand, R. Gref, S. Lesieur , H. Hommel, B. Vacher, M. Besnard, A. Besheer, K. Mäder, P. Couvreur:
    Physico-chemical characterization of polysaccharide-coated nanoparticles.
    Journal of Controlled Release 108, 97-111 (2005).
  2. C. Blümer, K. Mäder:
    Isostatic Ultra High Pressure Effects on Supercooled Melts in Colloidal Lipid Dispersions
    Pharmaceutical Research, 22(10), 1708-15. (2005).
  3. K. Jores, A. Haberland, S. Wartewig, K. Mäder, W. Mehnert:
    Solid lipid nanoparticles (SLN) and oil-loaded SLN as studied by spectrofluorometry and Raman spectroscopy.
    Pharmaceutical Research, 22, 1887-1897 (2005).
  4. A. Rübe, G. Hause, K. Mäder, J. Kohlbrecher:
    Core-Shell Structure of Miglyol/Poly(D,L-lactide)/Poloxamer Nanocapsules studied by Small-Angle Neutron Scattering
    Journal of Controlled Release 107, 244-252 (2005).
  5. D.J. Lurie, K. Mäder:
    Monitoring drug delivery processes by EPR and related techniques – principles and applications.
    Advanced Drug Delivery Reviews 57, 1171-1190 (2005).
  6. J.C. Richardson, R.W. Bowtell, K. Mäder, C.D. Melia:
    Pharmaceutical applications of Magnetic Resonance Imaging (MRI).
    Advanced Drug Delivery Reviews 57, 1191-1209 (2005).
  7. K. Mäder:
    Editorial of theme issue “Non-Invasive Spectroscopic and Imaging Techniques in Drug Delivery.”
    Advanced Drug Delivery Reviews 57, 1083-1084 (2005).
  8. A. Rübe, K. Mäder:
    An Electron Spin Resonance Study on the Dynamics of Polymeric Nanocapsules. Journal of Biomedical Nanotechnology. 1 , 208–213 (2005).


  1. C. Augsten, A. Rübe, M.A. Kiselev, R. Gehrke, K. Mäder:
    SAXS study of nanospheres consisting of poly(D,L-lactide-co-glycolide) and a poloxamer shell.
    HASYLAB Annual Report (2004)
  2. A. Lippacher, R.H. Müller, K. Mäder:
    Liquid and semisolid SLN dispersions for topical application: Rheological characterization.
    European Journal of Pharmaceutics and Biopharmaceutics 58 , 561–567 (2004).
  3. K. Jores , W. Mehnert, M. Drechsler , H. Bunjes , C. Johann , K. Mäder: Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy.
    Journal of Controlled Release, 95 (2) , 217-227 (2004).


  1. K. Jores, W. Mehnert, K. Mäder:
    Physicochemical investigations on solid lipid nanoparticles (SLN) and on oil-loaded solid lipid nanoparticles: a NMR- and ESR-study.
    Pharmaceutical Research 20 (8), 1274-1283 (2003).
  2. A. Steingötter, P. Kunz, D. Weishaupt, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, W. Schwizer:
    Analysis of the meal dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging (MRI).
    Alimentary Pharmacology and Therapeutics, 18 (7) 713-720 (2003).
  3. A. Steingötter, D. Weishaupt, P. Kunz, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, W. Schwizer:
    Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets.
    Pharmaceutical Research, 20 (12) 2001-2007 (2003).


A. Lippacher, R.H. Müller, K. Mäder:
Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties.
European Journal of Pharmaceutics and Biopharmaceutics 53, 155-160 (2002).


  1. W. Mehnert, K. Mäder:
    Solid lipid nanoparticles. Production, characterization and applications.
    Advanced Drug Delivery Reviews 47, 165-196 (2001).
  2. C.Kroll, W. Herrmann, R. Stösser, H.H. Borchert, K. Mäder:
    Influence of drug treatment on the microacidity in rat and human skin – an in vitro electron spin resonance imaging study.
    Pharmaceutical Research 18, 525-530 (2001).
  3. A. Lippacher, R.H. Müller, K. Mäder:
    Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles.
    International Journal of Pharmaceutics 214, 9-12 (2001).
  4. D. Teomim, K. Mäder, A. Bentolila, A. Magora, A.J. Domb:
    g-Irradiation stability of saturated and unsaturated aliphatic polyanhydrides-Ricinoleic Acid Based Polymers.
    Biomacromolecules 2, 1015-1022 (2001).


  1. B. Gallez, K. Mäder:
    Accurate and sensitive measurements of pO2 in vivo using low frequency EPR spectroscopy: how to confer biocompatibility to the oxygen sensors.
    Free Radical Biology & Medicine 29, 1078-1084 (2000).
  2. A. Lippacher, R.H. Müller, K. Mäder:
    Investigations on the viscoelastic properties of lipid based colloidal drug carriers.
    International Journal of Pharmaceutics, 196, 227-230 (2000).
  3. E. Zimmermann, R. H. Müller, K. Mäder:
    Influence of different parameters on reconstitution of lyophilized SLN
    International Journal of Pharmaceutics 196, 211-213 (2000).
  4. S. Liedtke, S. Wissing, R.H. Müller, K. Mäder:
    Influence of High Pressure Homogenisation Equipment on nanodispersions characteristics.
    International Journal of Pharmaceutics, 196, 183-185 (2000).
  5. I. Katzhendler, K. Mäder, R. Azoury, M. Friedman:
    Investigating the structure and properties of hydrated hydroxypropyl methyl cellulose and egg albumin matrixes containing carbamazepine: EPR and NMR study.
    Pharmaceutical Research, 17, 1299-1308 (2000).
  6. R.H. Müller, K. Mäder, K.; S. Gohla:
    Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
    European Journal of Pharmaceutics and Biopharmaceutics 50, 161-177 (2000).
  7. V. Jenning, K. Mäder, S.H. Gohla:
    Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a 1H-NMR study.
    International Journal of Pharmaceutics 205, 15-21 (2000).
  8. I. Katzhendler, K. Mäder, M. Friedman:
    Correlation between drug release kinetics from protein matrix and matrix structure: EPR and NMR study.
    Journal of Pharmaceutical Sciences, 89, 365-381 (2000).
  9. A. Gessner, R. Waicz, A. Lieske, B.-R. Paulke, K. Mäder, R.H. Müller:
    Nanoparticles with decreasing surface hydrophobicities : Influence on plasma protein absorption.
    International Journal of Pharmaceutics, 196, 245-249 (2000).
  10. K.P. Krause, O. Kayser, K. Mäder, R. Gust, R. H. Müller:
    Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation.
    International Journal of Pharmaceutics, 196, 169-172 (2000).
  11. K. Seehof, M. Kresse, K. Mäder, R.H. Müller:
    Interactions of nanoparticles with body proteins – improvement of 2D-Page analysis by internal standard.
    International Journal of Pharmaceutics, 196, 231-234 (2000).
  12. C. Witt, K. Mäder, T. Kissel:
    The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers
    Biomaterials 21, 931-938 (2000).
  13. I. Katzhendler, K. Mäder, M. Friedman:
    Structure and hydration properties of hydroxypropyl methyl cellulose matrices containing naproxen and naproxen sodium.
    International Journal of Pharmaceutics, 200, 161-179 (2000).

before 2000

  1. B. Bittner, C. Witt, K. Mäder, T. Kissel:
    Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblockcopolymers: Influence of buffer media on polymer erosion and bovine serum albumin release.
    Journal of Controlled Release, 60, 297-309 (1999).
  2. B. Bittner, K. Mäder, C. Kroll, H.H. Borchert, T. Kissel:
    Tetracycline-HCl loaded poly(DL-lactid-coglycolide) microspheres prepared by a spray drying technique: Influence of g-irradiation on radical formation and polymer degradation.
    Journal of Controlled Release, 59, 23-32 (1999).
  3. A. Brunner, K. Mäder, A. Göpferich:
    The microenvironment inside biodegradable microspheres: changes in pH and osmotic pressure.
    Pharmaceutical Research 16, 847-853 (1999).
  4. K. Mäder, B. Bittner, Y. Li, W. Wohlauf, T. Kissel:
    Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from polylactide-co-glycolide) (PLG) or ABA -triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethylenoxide) B blocks.
    Pharmaceutical Research 15, 787-793 (1998).
  5. K. Mäder:
    Pharmaceutical applications of in vivo EPR.
    Physics in Medicine and Biology, 43, 1-5 (1998).
  6. K. Mäder:
    Monitoring drug release and polymer erosion from therapeutically used biodegradable drug carriers by EPR and MRI in vitro and in vivo.
    Radiology and Oncology, 32, 89-94 (1998).
  7. A. Sotgiu, K. Mäder, G. Placidi, S. Colacicchi, C.L. Ursini and M. Alecci:
    pH-sensitive imaging by low-frequency EPR: a model study for biological applications.
    Phys. Med. Biol. 43, 1921–1930 (1998).
  8. K. Osterloh, C. Kroll, K. Mäder, H.-H. Borchert, B. Sammler, C. Kirmse:
    HPLC und Elektronenspinresonanz-Spektroskopie on-line gekoppelt.
    GIT Labor-Fachzeitschrift, 42, 24-25 (1998).
  9. Karsten Mäder:
    Pharmazeutische Anwendungen der Elektronenspinresonanz-Spektroskopie (ESR).
    PZ Prisma 5, 202-212 (1998).
  10. M.B. Sintzel, K. Schwach-Abdellaoui, K. Mäder, R. Stösser, J. Heller, C. Tabatabay, R. Gurny:
    Influence of irradiation sterilization on semi-solid poly(ortho ester).
    International Journal of Pharmaceutics 175, 165-176 (1998).
  11. K. Mäder, G. Bacic, A. Domb, O. Elmalak, R. Langer, H.M. Swartz:
    Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging.
    Journal of Pharmaceutical Sciences, 86, 126 - 134 (1997).
  12. K. Mäder, S. Nitschke, R. Stösser, H.-H. Borchert, A. Domb:
    Nondestructive and localised assesment of acidic microenvironments inside biodegradable polyanhydrides by spectral spatial Electron Paramagnetic Resonance Imaging (EPRI).
    Polymer 38, 4785-4794 (1997).
  13. K. Mäder, Y. Cremmilleux, A. Domb, J.F. Dunn and H.M. Swartz:
    In vitro / in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides - a noninvasive approach by the combined use of Electron Paramagnetic Resonance Spectroscopy and Nuclear Magnetic Resonance Imaging.
    Pharmaceutical Research 14, 820-826 (1997).
  14. K.J. Liu, K. Mäder, X. Shi, H.M. Swartz:
    Reduction of carcinogenic Cr(VI) on the skin of living rat.
    Magnetic Resonance in Medicine, 38, 524-526 (1997).
  15. R. Wiesner, J. Rathmann, H.G. Holzhütter, R. Stösser, K. Mäder, H. Nolting, H. Kuhn:
    Nitric oxide oxidises a ferrous mammalien lipoxygenase to a preactivated species.
    FEBS Letters. 389, 229-232, (1996).
  16. B. Gallez, K. Mäder, H.M. Swartz:
    Non-invasive measurement of the pH inside the gut using pH-sensitive nitroxides. An in vivo EPR study.
    Magnetic Resonance in Medicine 36, 694-697 (1996).
  17. K. Mäder, B. Gallez, H.M. Swartz:
    In vivo EPR: An effective new tool for studying pathophysiology, physiology, and pharmacology.
    Applied Radiation and Isotopes, 47, 1663-1667 (1996).
  18. K. Mäder, A. Domb, H.M. Swartz:
    Gamma sterilization induced radicals in biodegradable drug delivery systems.
    Applied Radiation and Isotopes, 47, 1669-1674 (1996).
  19. K. Mäder, B. Gallez, K.J. Liu, H.M.Swartz:
    Noninvasive in vivo characterization of release processes in biodegradable polymers by low frequency Electron Paramagnetic Resonance Spectroscopy.
    Biomaterials, 17, 459-463 (1996).
  20. C. Kroll, K. Mäder, R. Stoesser, H.-H. Borchert:
    Nondestructive determination of pH values in nontransparent W/O systems by means of EPR spectroscopy.
    European Journal of Pharmaceutical Sciences 3, 21-26 (1995).
  21. R. Stösser, K. Mäder, C. Kroll, H.-H. Borchert:
    In vitro and in vivo ESR in S- and X-band to monitor biopharmaceutical processes in mammalian skin.
    Magnetic Resonance in Medicine (Japan) 6, 349-351 (1995).
  22. H.H. Borchert, K. Mäder, R. Stösser, C. Kroll:
    Free radical intermediates in fungal metabolism as a model of mammalien drug metabolism
    Magnetic Resonance in Medicine (Japan) 6, 375-377 (1995).
  23. K. Mäder, G. Bacic, H.M. Swartz:
    In vivo detection of anthralin derived free radicals in the skin of hairless mice by low frequency electron paramagnetic resonance spectroscopy.
    Journal of Investigative Dermatology, 104, 514-517 (1995).
  24. K. Mäder, H.M. Swartz, R. Stösser, H.-H. Borchert:
    The application of EPR spectroscopy in the field of pharmacy.
    Pharmazie 49 , (2/3), 97-101 (1994).
  25. R. Stoesser, K. Maeder, H.-H. Borchert, R. Lueck:
    High pressure treatment of pharmaceutical drug delivery and related systems. High pressure research 13 , 29-33 (1994).
  26. K. Mäder, R. Stösser, H.-H. Borchert:
    Detection of free radicals in living mice after inhalation of DTBN by X-band ESR. Free Radical Biology & Medicine 14 , 339-342 (1993).
  27. A. Haberland , K. Mäder, R. Stößer, I. Schimke:
    Comparison of malondialdehyde and hydrogen peroxide modified CuZnSOD by EPR spectroscopy.
    Agents Actions 40 , 166-170 (1993).
  28. K. Mäder, R. Stößer, H.-H. Borchert:
    Transcutaneous absorption of nitroxide radicals detected in vivo by means of X-band ESR.
    Pharmazie 47 (12), 946-947 (1992).
  29. K. Mäder, H.-H.Borchert, R. Stößer, N.Groth, T. Herrling:
    Modelluntersuchungen zur Lokalisation und Mobilität von Arzneistoffen in Polymerfolien mit Hilfe der ESR-Tomographie.
    Pharmazie 46 , 439-442 (1991).
  30. K. Mäder, R. Stösser, H.-H. Borchert, R. Mank, B. Nerlich:
    ESR-Untersuchungen zur Wasserpenetration in Polymerfolien und Mikropartikel auf der Basis von biologisch abbaubaren Polyestern.
    Pharmazie 46 , 342 - 345 (1991).