Martin Luther University Halle-Wittenberg

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Publications Prof. Mäder (letzte 5 Jahre)

Peer-reviewed articles

2020

  1. D. Gerloff, J. Lützkendorf, R.K.C. Moritz, T. Wersig, K. Mäder, L.P. Müller, C. Sunderkötter: Melanoma derived exosomal miR-125b-5p educates tumor associated macrophages (TAMs) by targeting lysosomal acid lipase A (LIPA). Cancers, accepted (2020).
  2. E.F. Busmann, D.G. Martînez, H. Lucas, K. Mäder: Phase inversion-based production and characterization of isotonic MCT nanoemulsions as potential drug delivery system for parenteral applications. Beilstein Journal of Nanomedicine, 11, 213–224 (2020).
  3. C. Auch, C. Jede, M. Harms, C.Wagner, K. Mäder: Impact of amorphization and GI physiology on supersaturation and precipitation of poorly soluble weakly basic drugs using a small-scale in vitro transfer model. International Journal of Pharmaceutics, 574, 118917 (2020).
  4. B. Göttel, J.Martins de Souza e Silva, C. Santos de Oliveira, F. Syrowatka, M. Fiorentzis, A. Viestenz, A. Viestenz, K. Mäder: Electrospun nanofibers – a promising solid in-situ gelling alternative for ocular drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 146, 125-132 (2020).
  5. R. Alaneed, T. Hauenschild, K. Mäder, M. Pietzsch, J. Kressler: Conjugation of Amine-Functionalized Polyesters with Dimethylcasein Using Microbial Transglutaminase. Journal of Pharmaceutical Sciences, 109, 981-991, (2020).
  6. C. Fink, D. Sun, K. Wagner, M. Schneider, H. Bauer, H. Dolgos, K. Mäder, S. Peters: Evaluating the role of solubility in oral absorption of poorly water-soluble drugs using physiologically based pharmacokinetic (PBPK) modeling. Clinical Pharmacology & Therapeutics, 107, 650-661 (2020).

2019

  1. M. Kirchberg, S. Eick, M. Buchholz, A. Kiesow,  S. Sarembe, K. Mäder: Extrudates of Lipophilic Tetracycline Complexes: a  New Option for Periodontitis Therapy. International Journal of Pharmaceutics, 118794, DOI: 10.1016/j.ijpharm.2019.118794 (2019).
  2. C. Janich, A. Friedmann, J. Martins de Souza e Silva, C. Santos de Oliveira, L. Souza, M. Beck-Broichsitter, D. Rujescu, C. Hildebrandt, C.E.H. Schmelzer, K. Mäder: Risperidone loaded PLGA-Lipid particles with improved release kinetics: manufacturing and detailed characterization by electron microscopy and Nano-CT. Pharmaceutics, 11, 665; (2019).
  3. M.E.  Klein, S. Mauch, M. Rieckmann, G. Martinez, G. Hause, M. Noutsias, U.  Hofmann, H. Lucas, A. Meister, G. Ramos, H. Loppnow, K. Mäder: Phosphatidylserine (PS) and phosphatidylglycerol (PG) nanodispersions as  potential anti-inflammatory therapeutics: comparison of in vitro activity and impact of pegylation. Nanomedicine: Nanotechnology, Biology, and Medicine (Elsevier), 23, 102096, (2020).
  4. E.  Lehner, D. Gündel, A. Liebau, S. Plontke, K. Mäder: Intracochlear PLGA  based implants for dexamethasone release: challenges and solutions. International Journal of Pharmaceutics X, doi.org/10.1016/j.ijpx.2019.100015 (2019).
  5. M.H. Bilal, R. Alaneed, J. Steiner, K. Mäder, M. Pietzsch, J.Kressler: Multiple grafting to enzymatically synthesized polyesters. Methods in Enzymology, 627, 57-97, (2019).
  6. J. Strätz, A. Liedmann, M.L.  Trutschel, K. Mäder, T. Groth, S. Fischer: Development of hydrogels  based on oxidized cellulose sulfates and carboxymethyl chitosan. Cellulose, doi.org/10.1007/s10570-019-02596-6 (2019).
  7. C. Auch, M. Harms, Y. Golitsyn, D. Reichert, K. Mäder: Miniaturized measurement of drug-polymer interactions via viscosity increase for polymer selection in amorphous solid dispersions. Molecular Pharmaceutics, 16, 2214-2225, (2019).
  8. C. Zlomke, M. Barth, K. Mäder: Polymer degradation induced drug precipitation in PLGA implants – why less is sometimes more. European Journal of Pharmaceutics and Biopharmaceutics, 139, 142-152, (2019).
  9. M.  Riehl, M. Harms, B, Göttel, H. Kubas, D. Schiroky, K. Mäder: Acid induced degradation of widely used NIR dye DiR causes hypsochromic shift  in fluorescence properties. European Journal of Pharmaceutical Sciences, 132, 27-33, (2019).
  10. 10.  C. Auch, M. Harms, Karsten Mäder: How changes in molecular weight and  PDI of a polymer in amorphous solid dispersions impact dissolution  performance. International Journal of Pharmaceutics, 556, 372-382 (2019).
  11. 11. L. Lampp, O.Y. Rogozhnikova, D.V. Trukhin, V.M. Tormyshev, M.K. Bowman, N. Devasahayam, M.C. Krishna, K. Mäder, P. Imming: A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR.  Free Radical Biology and Medicine, 130, 120–127 (2019).

2018

  1. C. Auch, M. Harms, K. Mäder: Melt-based screening method with improved predictability regarding polymer selection for amorphous solid dispersions. European Journal of Pharmaceutical Sciences, 124, 339–348 (2018).
  2. T.  Wersig, R. Krombholz, C. Janich, A. Meister, J. Kressler, K. Mäder: Indomethacin functionalised poly(glycerol adipate) nanospheres as promising candidates for modified drug release. European Journal of Pharmaceutical Sciences, 123, 350-361 (2018).
  3. J.J. Stelzner, M. Behrens, S.E.  Behrens, K. Mäder: Squalene Containing Solid Lipid Nanoparticles, a  Promising Adjuvant System for the Immunisation with Yeast Vaccines. Vaccine, 36, 2314-2320 (2018).
  4. K.  Mäder, E. Lehner, A. Liebau, S., K. Plontke: Controlled drug release to  the inner ear: concepts, materials, mechanisms and performance. Hearing Research, https://doi.org/10.1016/j.heares.2018.03.006    (2018).
  5. M. Riehl, M. Harms, H. Lucas, T. Ebensen, C.A. Guzmán, K. Mäder: Dual dye in-vivo imaging of differentially charged PLGA carriers reveals antigen-depoteffect, leading to improved immune responses in preclinical models. European Journal of Pharmaceutical Sciences, 117, 88-97, (2018).
  6. V.  Weiss, H. Lucas, T. Mueller, P. Chytil, T. Etrych, T. Naolou, J. Kressler, K. Mäder: Intended and Unintended Targeting of Polymeric Nanocarriers: TheCase of Modified Poly(glycerol adipate) Nanoparticles. Macromolecular Bioscience, DOI:10.10002/mabi.201700240    (2018).

2017

  1. M. Riehl, M. Harms, A. Hanefeld, R.B. Baleeiro, P. Walden, K. Mäder: Combining R-DOTAP and a particulate antigen delivery platform to trigger dendritic cellactivation: formulation development and in-vitro interaction studies. International Journal of Pharmaceutics, 532, 37–46, (2017).
  2. D.  Bär, H. Debus, C. Grune, S. Tosch, W. Fischer, K. Mäder, P. Imming: Improving the drug release of Naproxen Sodium tablets by preparing granules andtablets with a preferred mixing ratio of hydrates. European Journal of Pharmaceutics and Biopharmaceutics 121, 90–96, (2017).
  3. T. Wersig, M.C.  Hacker, J. Kressler and K. Mäder: Poly(glycerol adipate) – Indomethacin  Drug Conjugates – Synthesis and in vitro Characterization. International Journal of Pharmaceutics, 531, 225-234, (2017).
  4. Y.K. Demir, A.Ü. Metin, B. Şatıroğlu, M.E. Solmaz, V. Kayser, K. Mäder:Poly (methyl vinyl ether-co-maleic acid) – Pectin Based Hydrogel-Forming Systems: Gel, Film, and Microneedles. European Journal of Pharmaceutics and Biopharmaceutics, 117, 182–194 (2017).
  5. M.H.  Bilal, H. Hussain, M. Prehm, U. Baumeister, A. Meister, G. Hause, K.  Busse, K. Mäder, J. Kressler: Synthesis of Poly(glycerol adipate)-g-Oleate and its Ternary Phase Diagram with Glycerol Monooleate and Water. European Polymer Journal, 91, 162–175 (2017).
  6. M. Elewa, N. Maltar-Strmečki, M.M. Said, H.A. El Shihawy, M. El-Sadek, J. Frank, S. Drescher, M. Drescher, K. Mäder, D. Hinderberger, P. Imming: Synthesis and EPR –spectroscopic characterization of the perchlorotriaryl-methyl tricarboxylic acid radical (PTMTC) and its 13C labelled analogue (13C-PTMTC). Physical Chemistry Chemical Physics, 19, 6688-6697 (2017).

2016

  1. M. Heider, G. Hause, K. Mäder: Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility  of lipid drug delivery systems? A case study on solid lipid  nanoparticles (SLN). European Journal of Pharmaceutics and Biopharmaceutics, 109, 194-205 (2016).
  2. A.  Mante, M. Heider, C. Zlomke, K. Mäder: PLGA nanoparticles for peroral  delivery: How important is pancreatic digestion and can we control it? European Journal of Pharmaceutics and Biopharmaceutics, 108, 32-40 (2016).
  3. R.  Pola, A.-K. Heinrich, T. Mueller, L. Kostka, K. Mäder, M. Pechar, T. Etrych: Passive tumor targeting of polymer therapeutics: In vivo imaging of both the polymer carrier and the enzymatically cleavable drug model. Macromolecular Bioscience. 6, 1577-1582 (2016).
  4. T. Etrych, H. Lucas, O. Janouskova, P. Chytil, T. Müller, K. Mäder: Fluorescence Optical Imaging in anticancer drug delivery.Journal of Controlled Release, 226, 168-181, (2016).
  5. A.-K.  Heinrich, H. Lucas, L. Schindler, P. Chytil, T. Etrych, K. Mäder, T. MuellerImproved tumor specific drug accumulation by polymer therapeutics  with pH-sensitive drug release overcomes chemotherapy resistance. Molecular Cancer Therapeutics, 15 (5), 998-1007, (2016).
  6. M. Studenovsky, A.-K. Heinrich, H. Lucas, T. Mueller, K. Mäder, T. Etrych: Dual fluorescent HPMA-based  conjugates for passive tumor targeting with reductionsensitive drug  release: Proof of the concept, tumor accumulation and biodistribution. Journal of Bioactive and Compatible Polymers, 31, 348-360, (2016).
  7. M. Bachmann, M. Wensch-Dorendorf,  K. Mäder, M. Bulang, A. Zeyner: Preparation of synthetic alkane waxes  and investigations on their suitability for application as dietary  markers in farm animals. Livestock Science, 185,110–116 (2016).
  8. Y. Yang, A. Köwitsch, N. Ma, K. Mäder, I. Pashkuleva, R.L. Reis, T. Groth: Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion. Journal of Bioactive and Compatible Polymers, 31, 191-207 (2016).

2015

  1. J. Frank, D. Gündel, S. Drescher, O. Thews, K. Mäder: Injectable LiNc-BuO loaded microspheres as in vivo EPR oxygen sensors after co-implantation with tumor cells. Free Radical Biology & Medicine, 89, 741–749 (2015).
  2. J. Walldorf, M. Hermann, M. Porzner, S. Pohl, H. Metz, K. Mäder, A. Zipprich, B. Christ, T. Seufferlein: In-vivo monitoring of acute DSS-colitis using colonoscopy, high resolution ultrasonography and bench-top magnetic resonance imaging in mice. European Radiology, 25, 2984-2991 (2015).
  3. J. Frank, M. Elewa, M. Said, H. Elshihawy, M. El-Sadek,  D. Mueller, A. Meister, G. Hause, S. Drescher, H. Metz, P. Imming, K.  Mäder: Synthesis, characterization, and nanoencapsulation of tetrathiatriarylmethyl and tetrachlorotriarylmethyl (trityl) radical derivatives. A study to advance their applicability as in vivo EPR oxygen sensors. Journal of Organic Chemistry, 80, 6754–6766 (2015).
  4. M. Riehl, M. Harms, A. Hanefeld, K. Mäder: Investigation of the stabilizer elimination during the washing step of charged PLGA microparticles utilizing a novel HPLC-UV-ELSD method. European Journal of Pharmaceutics and Biopharmaceutics, 94, 468–472 (2015).
  5. T.H. Hassan, K. Mäder: Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion. International Journal of Pharmaceutics 486, 77-87 (2015).
  6. M.P. Do, C. Neut, H. Metz, E. Delcourt, J. Siepmann, K. Mäder, F. Siepmann: Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment. European Journal of Pharmaceutics and Biopharmaceutics94, 273–283, (2015).
  7. M.P.Do, C. Neut, H. Metz, E. Delcourt, K. Mäder, J. Siepmann, F. Siepmann: In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance. International Journal of Pharmaceutics 486, 38-51 (2015).
  8. A. Belete, H.  Metz, T. Mueller, K.  Maeder: Benchtop MRI for pharmacokinetic evaluation of two aqueous-based nano-scaled formulations of oleic acid stabilized magnetite nanocrystals. Drug Development and Industrial Pharmacy,41 (3), 406-414 (2015).

Book and book chapters

2019

  1. M.H. Bilal, R. Alaneed, J. Steiner, K.  Mäder, M. Pietzsch, J. Kressler: Multipl Grafting to Enzymatically  Synthesized Polyesters. In: Methods in Enzymology, Volume 627, Enzymatic  Polymerizations, Serial Volume Editors: N. Bruns, K. Loos; ISBN:  9780128170953, Academic Press,

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