Publications Prof. Mäder (letzte 5 Jahre)
Peer-reviewed articles
2020
- D. Gerloff, J. Lützkendorf, R.K.C. Moritz, T. Wersig, K. Mäder, L.P. Müller, C. Sunderkötter: Melanoma derived exosomal miR-125b-5p educates tumor associated macrophages (TAMs) by targeting lysosomal acid lipase A (LIPA). Cancers, accepted (2020).
- E.F. Busmann, D.G. Martînez, H. Lucas, K. Mäder: Phase inversion-based production and characterization of isotonic MCT nanoemulsions as potential drug delivery system for parenteral applications. Beilstein Journal of Nanomedicine, 11, 213–224 (2020).
- C. Auch, C. Jede, M. Harms, C.Wagner, K. Mäder: Impact of amorphization and GI physiology on supersaturation and precipitation of poorly soluble weakly basic drugs using a small-scale in vitro transfer model. International Journal of Pharmaceutics, 574, 118917 (2020).
- B. Göttel, J.Martins de Souza e Silva, C. Santos de Oliveira, F. Syrowatka, M. Fiorentzis, A. Viestenz, A. Viestenz, K. Mäder: Electrospun nanofibers – a promising solid in-situ gelling alternative for ocular drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 146, 125-132 (2020).
- R. Alaneed, T. Hauenschild, K. Mäder, M. Pietzsch, J. Kressler: Conjugation of Amine-Functionalized Polyesters with Dimethylcasein Using Microbial Transglutaminase. Journal of Pharmaceutical Sciences, 109, 981-991, (2020).
- C. Fink, D. Sun, K. Wagner, M. Schneider, H. Bauer, H. Dolgos, K. Mäder, S. Peters: Evaluating the role of solubility in oral absorption of poorly water-soluble drugs using physiologically based pharmacokinetic (PBPK) modeling. Clinical Pharmacology & Therapeutics, 107, 650-661 (2020).
2019
- M. Kirchberg, S. Eick, M. Buchholz, A. Kiesow, S. Sarembe, K. Mäder: Extrudates of Lipophilic Tetracycline Complexes: a New Option for Periodontitis Therapy. International Journal of Pharmaceutics, 118794, DOI: 10.1016/j.ijpharm.2019.118794 (2019).
- C. Janich, A. Friedmann, J. Martins de Souza e Silva, C. Santos de Oliveira, L. Souza, M. Beck-Broichsitter, D. Rujescu, C. Hildebrandt, C.E.H. Schmelzer, K. Mäder: Risperidone loaded PLGA-Lipid particles with improved release kinetics: manufacturing and detailed characterization by electron microscopy and Nano-CT. Pharmaceutics, 11, 665; (2019).
- M.E. Klein, S. Mauch, M. Rieckmann, G. Martinez, G. Hause, M. Noutsias, U. Hofmann, H. Lucas, A. Meister, G. Ramos, H. Loppnow, K. Mäder: Phosphatidylserine (PS) and phosphatidylglycerol (PG) nanodispersions as potential anti-inflammatory therapeutics: comparison of in vitro activity and impact of pegylation. Nanomedicine: Nanotechnology, Biology, and Medicine (Elsevier), 23, 102096, (2020).
- E. Lehner, D. Gündel, A. Liebau, S. Plontke, K. Mäder: Intracochlear PLGA based implants for dexamethasone release: challenges and solutions. International Journal of Pharmaceutics X, doi.org/10.1016/j.ijpx.2019.100015 (2019).
- M.H. Bilal, R. Alaneed, J. Steiner, K. Mäder, M. Pietzsch, J.Kressler: Multiple grafting to enzymatically synthesized polyesters. Methods in Enzymology, 627, 57-97, (2019).
- J. Strätz, A. Liedmann, M.L. Trutschel, K. Mäder, T. Groth, S. Fischer: Development of hydrogels based on oxidized cellulose sulfates and carboxymethyl chitosan. Cellulose, doi.org/10.1007/s10570-019-02596-6 (2019).
- C. Auch, M. Harms, Y. Golitsyn, D. Reichert, K. Mäder: Miniaturized measurement of drug-polymer interactions via viscosity increase for polymer selection in amorphous solid dispersions. Molecular Pharmaceutics, 16, 2214-2225, (2019).
- C. Zlomke, M. Barth, K. Mäder: Polymer degradation induced drug precipitation in PLGA implants – why less is sometimes more. European Journal of Pharmaceutics and Biopharmaceutics, 139, 142-152, (2019).
- M. Riehl, M. Harms, B, Göttel, H. Kubas, D. Schiroky, K. Mäder: Acid induced degradation of widely used NIR dye DiR causes hypsochromic shift in fluorescence properties. European Journal of Pharmaceutical Sciences, 132, 27-33, (2019).
- 10. C. Auch, M. Harms, Karsten Mäder: How changes in molecular weight and PDI of a polymer in amorphous solid dispersions impact dissolution performance. International Journal of Pharmaceutics, 556, 372-382 (2019).
- 11. L. Lampp, O.Y. Rogozhnikova, D.V. Trukhin, V.M. Tormyshev, M.K. Bowman, N. Devasahayam, M.C. Krishna, K. Mäder, P. Imming: A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR. Free Radical Biology and Medicine, 130, 120–127 (2019).
2018
- C. Auch, M. Harms, K. Mäder: Melt-based screening method with improved predictability regarding polymer selection for amorphous solid dispersions. European Journal of Pharmaceutical Sciences, 124, 339–348 (2018).
- T. Wersig, R. Krombholz, C. Janich, A. Meister, J. Kressler, K. Mäder: Indomethacin functionalised poly(glycerol adipate) nanospheres as promising candidates for modified drug release. European Journal of Pharmaceutical Sciences, 123, 350-361 (2018).
- J.J. Stelzner, M. Behrens, S.E. Behrens, K. Mäder: Squalene Containing Solid Lipid Nanoparticles, a Promising Adjuvant System for the Immunisation with Yeast Vaccines. Vaccine, 36, 2314-2320 (2018).
- K. Mäder, E. Lehner, A. Liebau, S., K. Plontke: Controlled drug release to the inner ear: concepts, materials, mechanisms and performance. Hearing Research, https://doi.org/10.1016/j.heares.2018.03.006 (2018).
- M. Riehl, M. Harms, H. Lucas, T. Ebensen, C.A. Guzmán, K. Mäder: Dual dye in-vivo imaging of differentially charged PLGA carriers reveals antigen-depoteffect, leading to improved immune responses in preclinical models. European Journal of Pharmaceutical Sciences, 117, 88-97, (2018).
- V. Weiss, H. Lucas, T. Mueller, P. Chytil, T. Etrych, T. Naolou, J. Kressler, K. Mäder: Intended and Unintended Targeting of Polymeric Nanocarriers: TheCase of Modified Poly(glycerol adipate) Nanoparticles. Macromolecular Bioscience, DOI:10.10002/mabi.201700240 (2018).
2017
- M. Riehl, M. Harms, A. Hanefeld, R.B. Baleeiro, P. Walden, K. Mäder: Combining R-DOTAP and a particulate antigen delivery platform to trigger dendritic cellactivation: formulation development and in-vitro interaction studies. International Journal of Pharmaceutics, 532, 37–46, (2017).
- D. Bär, H. Debus, C. Grune, S. Tosch, W. Fischer, K. Mäder, P. Imming: Improving the drug release of Naproxen Sodium tablets by preparing granules andtablets with a preferred mixing ratio of hydrates. European Journal of Pharmaceutics and Biopharmaceutics 121, 90–96, (2017).
- T. Wersig, M.C. Hacker, J. Kressler and K. Mäder: Poly(glycerol adipate) – Indomethacin Drug Conjugates – Synthesis and in vitro Characterization. International Journal of Pharmaceutics, 531, 225-234, (2017).
- Y.K. Demir, A.Ü. Metin, B. Şatıroğlu, M.E. Solmaz, V. Kayser, K. Mäder:Poly (methyl vinyl ether-co-maleic acid) – Pectin Based Hydrogel-Forming Systems: Gel, Film, and Microneedles. European Journal of Pharmaceutics and Biopharmaceutics, 117, 182–194 (2017).
- M.H. Bilal, H. Hussain, M. Prehm, U. Baumeister, A. Meister, G. Hause, K. Busse, K. Mäder, J. Kressler: Synthesis of Poly(glycerol adipate)-g-Oleate and its Ternary Phase Diagram with Glycerol Monooleate and Water. European Polymer Journal, 91, 162–175 (2017).
- M. Elewa, N. Maltar-Strmečki, M.M. Said, H.A. El Shihawy, M. El-Sadek, J. Frank, S. Drescher, M. Drescher, K. Mäder, D. Hinderberger, P. Imming: Synthesis and EPR –spectroscopic characterization of the perchlorotriaryl-methyl tricarboxylic acid radical (PTMTC) and its 13C labelled analogue (13C-PTMTC). Physical Chemistry Chemical Physics, 19, 6688-6697 (2017).
2016
- M. Heider, G. Hause, K. Mäder: Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN). European Journal of Pharmaceutics and Biopharmaceutics, 109, 194-205 (2016).
- A. Mante, M. Heider, C. Zlomke, K. Mäder: PLGA nanoparticles for peroral delivery: How important is pancreatic digestion and can we control it? European Journal of Pharmaceutics and Biopharmaceutics, 108, 32-40 (2016).
- R. Pola, A.-K. Heinrich, T. Mueller, L. Kostka, K. Mäder, M. Pechar, T. Etrych: Passive tumor targeting of polymer therapeutics: In vivo imaging of both the polymer carrier and the enzymatically cleavable drug model. Macromolecular Bioscience. 6, 1577-1582 (2016).
- T. Etrych, H. Lucas, O. Janouskova, P. Chytil, T. Müller, K. Mäder: Fluorescence Optical Imaging in anticancer drug delivery.Journal of Controlled Release, 226, 168-181, (2016).
- A.-K. Heinrich, H. Lucas, L. Schindler, P. Chytil, T. Etrych, K. Mäder, T. MuellerImproved tumor specific drug accumulation by polymer therapeutics with pH-sensitive drug release overcomes chemotherapy resistance. Molecular Cancer Therapeutics, 15 (5), 998-1007, (2016).
- M. Studenovsky, A.-K. Heinrich, H. Lucas, T. Mueller, K. Mäder, T. Etrych: Dual fluorescent HPMA-based conjugates for passive tumor targeting with reductionsensitive drug release: Proof of the concept, tumor accumulation and biodistribution. Journal of Bioactive and Compatible Polymers, 31, 348-360, (2016).
- M. Bachmann, M. Wensch-Dorendorf, K. Mäder, M. Bulang, A. Zeyner: Preparation of synthetic alkane waxes and investigations on their suitability for application as dietary markers in farm animals. Livestock Science, 185,110–116 (2016).
- Y. Yang, A. Köwitsch, N. Ma, K. Mäder, I. Pashkuleva, R.L. Reis, T. Groth: Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion. Journal of Bioactive and Compatible Polymers, 31, 191-207 (2016).
2015
- J. Frank, D. Gündel, S. Drescher, O. Thews, K. Mäder: Injectable LiNc-BuO loaded microspheres as in vivo EPR oxygen sensors after co-implantation with tumor cells. Free Radical Biology & Medicine, 89, 741–749 (2015).
- J. Walldorf, M. Hermann, M. Porzner, S. Pohl, H. Metz, K. Mäder, A. Zipprich, B. Christ, T. Seufferlein: In-vivo monitoring of acute DSS-colitis using colonoscopy, high resolution ultrasonography and bench-top magnetic resonance imaging in mice. European Radiology, 25, 2984-2991 (2015).
- J. Frank, M. Elewa, M. Said, H. Elshihawy, M. El-Sadek, D. Mueller, A. Meister, G. Hause, S. Drescher, H. Metz, P. Imming, K. Mäder: Synthesis, characterization, and nanoencapsulation of tetrathiatriarylmethyl and tetrachlorotriarylmethyl (trityl) radical derivatives. A study to advance their applicability as in vivo EPR oxygen sensors. Journal of Organic Chemistry, 80, 6754–6766 (2015).
- M. Riehl, M. Harms, A. Hanefeld, K. Mäder: Investigation of the stabilizer elimination during the washing step of charged PLGA microparticles utilizing a novel HPLC-UV-ELSD method. European Journal of Pharmaceutics and Biopharmaceutics, 94, 468–472 (2015).
- T.H. Hassan, K. Mäder: Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion. International Journal of Pharmaceutics 486, 77-87 (2015).
- M.P. Do, C. Neut, H. Metz, E. Delcourt, J. Siepmann, K. Mäder, F. Siepmann: Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment. European Journal of Pharmaceutics and Biopharmaceutics94, 273–283, (2015).
- M.P.Do, C. Neut, H. Metz, E. Delcourt, K. Mäder, J. Siepmann, F. Siepmann: In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance. International Journal of Pharmaceutics 486, 38-51 (2015).
- A. Belete, H. Metz, T. Mueller, K. Maeder: Benchtop MRI for pharmacokinetic evaluation of two aqueous-based nano-scaled formulations of oleic acid stabilized magnetite nanocrystals. Drug Development and Industrial Pharmacy,41 (3), 406-414 (2015).
Book and book chapters
2019
- M.H. Bilal, R. Alaneed, J. Steiner, K. Mäder, M. Pietzsch, J. Kressler: Multipl Grafting to Enzymatically Synthesized Polyesters. In: Methods in Enzymology, Volume 627, Enzymatic Polymerizations, Serial Volume Editors: N. Bruns, K. Loos; ISBN: 9780128170953, Academic Press,